The Center for Hierarchical Materials Design (CHiMaD) represents a Chicago-based consortium of the University of Chicago, Northwestern University, Northwestern-Argonne Institute for Science and Engineering (NAISE) that is a partnership between Argonne National Laboratory and Northwestern, and the Computational Institute that is a partnership between the University of Chicago and Argonne. It serves together with NIST and AFRL as a national resource for the verified codes and curated databases that will enable proliferation of a materials-by-design strategy throughout US industrial partners. Numerous materials “use cases” of industrial relevance drive purposeful method and tool development, while aiding transfer to industry of both the new principles of computational materials design. Demonstrating a broad methodology for multicomponent, multiphase materials spanning metals and polymers for structural and multifunctional applications.